Nature Communications (Mar 2021)
Neurofilament light chain as a potential biomarker for monitoring neurodegeneration in X-linked adrenoleukodystrophy
- Isabelle Weinhofer,
- Paulus Rommer,
- Bettina Zierfuss,
- Patrick Altmann,
- Martha Foiani,
- Amanda Heslegrave,
- Henrik Zetterberg,
- Andreas Gleiss,
- Patricia L. Musolino,
- Yi Gong,
- Sonja Forss-Petter,
- Thomas Berger,
- Florian Eichler,
- Patrick Aubourg,
- Wolfgang Köhler,
- Johannes Berger
Affiliations
- Isabelle Weinhofer
- Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna
- Paulus Rommer
- Department of Neurology, Medical University of Vienna
- Bettina Zierfuss
- Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna
- Patrick Altmann
- Department of Neurology, Medical University of Vienna
- Martha Foiani
- UK Dementia Research Institute at UCL
- Amanda Heslegrave
- UK Dementia Research Institute at UCL
- Henrik Zetterberg
- UK Dementia Research Institute at UCL
- Andreas Gleiss
- Section for Clinical Biometrics, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna
- Patricia L. Musolino
- Department of Neurology, Harvard Medical School, Massachusetts General Hospital
- Yi Gong
- Department of Neurology, Harvard Medical School, Massachusetts General Hospital
- Sonja Forss-Petter
- Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna
- Thomas Berger
- Department of Neurology, Medical University of Vienna
- Florian Eichler
- Department of Neurology, Harvard Medical School, Massachusetts General Hospital
- Patrick Aubourg
- Kremlin-Bicêtre Hospital, University Paris-Saclay
- Wolfgang Köhler
- Department of Neurology, Leukodystrophy Clinic, University of Leipzig Medical Center
- Johannes Berger
- Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna
- DOI
- https://doi.org/10.1038/s41467-021-22114-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
X-linked adrenoleukodystophy (X-ALD) is a highly variable, progressive neurodegenerative disorder. In this study, neurofilament light chain protein (NfL) was identified as a potential early distinguishing biomarker.
