Nature Communications (Feb 2018)

BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage

  • Kajal Biswas,
  • Subha Philip,
  • Aditya Yadav,
  • Betty K. Martin,
  • Sandra Burkett,
  • Vaibhav Singh,
  • Anav Babbar,
  • Susan Lynn North,
  • Suhwan Chang,
  • Shyam K. Sharan

DOI
https://doi.org/10.1038/s41467-018-03020-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Loss of BRCA2 leads to cancer formation. Here, the authors use an insertional mutagenesis approach and identify a multiprotein complex consisting of BRE, USP7 and CDC25A that can support the survival of BRCA2-deficient cells.