Nature Communications (Jun 2016)

Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice

  • V. Beglopoulos,
  • J. Tulloch,
  • A. D. Roe,
  • S. Daumas,
  • L. Ferrington,
  • R. Watson,
  • Z. Fan,
  • B. T. Hyman,
  • P. A. T. Kelly,
  • F. Bard,
  • R. G. M. Morris

DOI
https://doi.org/10.1038/ncomms11761
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Identifying early signs of Alzheimer’s disease is important when it comes to diagnosis and treatment. Here, the authors identify subtle memory retrieval deficits and associated brain glucose uptake impairments in very young mouse models of Alzheimer’s, prior to plaque development.