Development of New Formulation of Inosine Acedoben Dimepranol Powder for Oral Solution in Sachets

Abstract

Inosine Acedoben Dimepranol (IAD) has immunomodulatory and antiviral properties and is used in the treatment of viral infections. The aim of the present study was to develop a powder for oral solution in sachets containing high dose IAD (1000 mg). The formulations were prepared by direct dry mixing of the components using the dilution principle. Optimal composition and process parameters for the development of high dosage powder were established. Solubility studies showed pH-dependent solubility of IAD. The prepared powder was characterized by a short reconstitution time. In addition, the oral solution exhibits good organoleptic properties and remains stable for 30 min. Stability studies indicated that the sachets remained stable under accelerated conditions for 3 months. In conclusion, the developed powder for oral solution in sachets containing 1000 mg IAD represents an economical alternative to other solid dosage forms with the advantages of rapid dissolution and convenient intake for the patient.

Keywords

• inosine acedoben dimepranol (iad)
• powder for oral solution in sachets
• reconstitution
• solubility
• spray-dried mannitol
• stability