Ciência Rural (Oct 2024)

Conidiobolomycosis with neurological commitment in sheep in Pará, Brazil

  • Camila Cordeiro Barbosa,
  • Carlos Eduardo da Silva Ferreira Filho,
  • Natália da Silva e Silva Silveira,
  • Carlos Magno Chaves Oliveira,
  • Tatiane Teles Albernaz Ferreira,
  • José Alcides Sarmento da Silveira,
  • Marcos Dutra Duarte,
  • Paulo Sérgio Chagas da Costa,
  • Gabriela Oliveira Pereira,
  • Marilene de Farias Brito,
  • José Diomedes Barbosa

DOI
https://doi.org/10.1590/0103-8478cr20240016
Journal volume & issue
Vol. 55, no. 2

Abstract

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ABSTRACT: The study was conducted on a 3-year-old female Santa Inês sheep from a property located in the municipality of Santo Antônio de Tauá, west of Pará. The affected animal had a history of exophthalmos in the left eye, nasal discharge, and breathing difficulty for more than three months. On physical examination, the animal had a low body score, apathy, unilateral facial asymmetry, moderate unilateral left exophthalmos, mixed dyspnea and unilateral profuse serosanguinous nasal discharge. At necropsy, a large nasal mass was observed, predominantly yellowish-white with blackish-red areas, with an irregular, finely granular, moist, and friable surface. The mass invaded from the mucocutaneous junction of the left nostril to the choanae, infiltrated the frontal sinuses, the cribiform plate, and reached the meninges and the frontal portion of the brain. Microscopy of the surface of the nasal epithelium showed severe destruction of the turbinates and epithelia, evidenced by extensive areas of necrosis with a large amount of cellular debris, ulceration, and secondary bacterial infection. In the central nervous system there was pyogranulomatous meningitis with marked vessel congestion, as well as foci of necrosis and granulomatous inflammation. Immunohistochemistry showed intense staining of numerous intralesional hyphae for antibodies against Conidiobolus lamprauges. The diagnosis of granulomatous rhinitis of mycotic origin associated with the Conidiobolus lamprauges was based on epidemiological, clinical-pathological, and immunohistochemical data.

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