Nature Communications (Oct 2022)
Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation
- Sang-A Park,
- Yun-Ji Lim,
- Wai Lim Ku,
- Dunfang Zhang,
- Kairong Cui,
- Liu-Ya Tang,
- Cheryl Chia,
- Peter Zanvit,
- Zuojia Chen,
- Wenwen Jin,
- Dandan Wang,
- Junji Xu,
- Ousheng Liu,
- Fu Wang,
- Alexander Cain,
- Nancy Guo,
- Hiroko Nakatsukasa,
- Chuan Wu,
- Ying E. Zhang,
- Keji Zhao,
- WanJun Chen
Affiliations
- Sang-A Park
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Yun-Ji Lim
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Wai Lim Ku
- Systemic Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
- Dunfang Zhang
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Kairong Cui
- Systemic Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
- Liu-Ya Tang
- Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Cheryl Chia
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Peter Zanvit
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Zuojia Chen
- Experimental Immunology Branch, National Cancer Institute, National Institutes of Health
- Wenwen Jin
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Dandan Wang
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Junji Xu
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Ousheng Liu
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Fu Wang
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Alexander Cain
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Nancy Guo
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Hiroko Nakatsukasa
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- Chuan Wu
- Experimental Immunology Branch, National Cancer Institute, National Institutes of Health
- Ying E. Zhang
- Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health
- Keji Zhao
- Systemic Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health
- WanJun Chen
- Mucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-022-33733-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
IL-9-producing CD4 T (Th9) cells have been implicated in allergy and tumor immunity, but how their differentiation is regulated by TGFβ is still unclear. Here the authors show that two transcription factors, DBP and E2F8, institute opposing effects on IL-9 expression downstream of TGFβ/Smad3 linker region-mediated signaling in activated mouse T cells to modulate antitumor responses.
