Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro

Elisabeth Maurer; Maria Aigner; Cornelia Lass-Flörl; Ulrike Binder

doi:10.3390/jof5030061

Journal of Fungi (Jul 2019)

Hypoxia Decreases Diagnostic Biomarkers for Aspergillosis In Vitro

Elisabeth Maurer,
Maria Aigner,
Cornelia Lass-Flörl,
Ulrike Binder

Affiliations

Elisabeth Maurer: Department of Hygiene, Medical Microbiology and Public Health, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria
Maria Aigner: Department of Hygiene, Medical Microbiology and Public Health, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria
Cornelia Lass-Flörl: Department of Hygiene, Medical Microbiology and Public Health, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria
Ulrike Binder: Department of Hygiene, Medical Microbiology and Public Health, Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstrasse 41, 6020 Innsbruck, Austria

DOI: https://doi.org/10.3390/jof5030061
Journal volume & issue: Vol. 5, no. 3
p. 61

Abstract

Read online

The aim of the study was to evaluate the influence of hypoxia on galactomannan and (1,3)-β-d-glucan release of clinically relevant Aspergilli in vitro. Hypoxia decreased biomass and consequently led to lower biomarker release. However, when normalized to biomass, hypoxia led to increased levels of biomarkers at early growth stages (24 h). Antifungals (amphotericin B and voriconazole) decreased the galactomannan amount of A. fumigatus, even more prominently in hypoxia.

Published in Journal of Fungi

ISSN: 2309-608X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/jof

About the journal

Abstract

Keywords