Zaporožskij Medicinskij Žurnal (Apr 2017)
Relationship between disorders of adipose tissue hormones and interleukins in patients with hypertension and comorbid pathology
Abstract
The purpose of research – was to improve the efficiency of diagnostics of arterial hypertension (AH) with comorbid disorders (diabetes mellitus (DM) and obesity) by studying hormones of adipose tissue (leptin and adiponectin) and the inflammatory markers – interleukin 6 and 10. Material and methods. The study involved 195 hypertensive patients, who were divided into 2 groups. 1st group consisted of 96 patients with stage I hypertension, which included patients with isolated AH ‑ 21 patients with hypertension and diabetes ‑ 27 patients with hypertension and obesity, and 25 patients with hypertension, diabetes and obesity of 23 patients. 99 patients, who had been diagnosed with hypertension stage II, were included into the II-nd group. The 2nd group was divided into 4 subgroups: the 1st subgroup consisted of 23 patients with isolated AH, 2nd – 24 hypertensive patients with diabetes, 3rd – 27 patients with obesity and 4th – 25 hypertensive patients with diabetes and obesity. The study also included 20 people with no signs of hypertension, diabetes and obesity as a control group. The test parameters were determined by ELISA. Results. It was founded that leptin level were increased and adiponectin level was decreased in hypertensive patients with or without combination with diabetes, and only when combined both with obesity and diabetes, patients have achieved credibility. Interleukin 6 and 10 levels were increased in patients with isolated hypertension and in conjunction with DM in comparison with the control group. This increase was significant only in combination with obesity and both with diabetes and obesity. Any significant differences were not established in studied parameters between the stages of hypertension. Conclusions. Leptin and adiponectin level detection, as well as inflammatory markers ‑ interleukin 6 and 10, helps to improve diagnosis of hypertension with comorbid pathologies (diabetes and obesity). ;hypertension; obesity; diabetes mellitus; interleukins; adiponectin interleukins; adiponectin
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