Research status of inorganic antibacterial coatings for orthopedic implants

Abstract

Implant infection is one of the most common and serious complications in orthopedics, and it is also an important reason for the failure of implant surgery. When bacteria form a biofilm on the implant surface, it is extremely difficult to be eliminated and attracts more bacteria and fungi. A large number of studies have shown that the use of surface modification technology can effectively reduce the adhesion and accumulation of pathogenic bacteria, thereby preventing peri-implant infection. The formation process of bacterial biofilm on the surface of orthopedic implants and the antibacterial mechanism of metal antibacterial agents were first analyzed. Then, some of the most widely used metal-based inorganic antibacterial coatings at home and abroad and their related preparation processes were reviewed, the problems and improvement methods in the application of these coatings were also discussed, and the development direction of inorganic antibacterial coatings in the future was prospected, such as synergistic antibacterial coatings and bone-promoting antibacterial coatings.

Keywords

• orthopedic implant
• inorganic antibacterial coating
• preparation process
• tissue structure
• biocompatibility
• silver nanoparticle