Nanomaterials
(Dec 2022)
CeO<sub>2</sub>-Azacrown Conjugate as a Nanoplatform for Combined Radiopharmaceuticals
Sofia Khabirova,
Gleb Aleshin,
Tatiana Plakhova,
Anastasia Zubenko,
Anna Shchukina,
Olga Fedorova,
Aleksey Averin,
Ekaterina Belova,
Elena Bazarkina,
Kristina Kvashnina,
Stepan Kalmykov
Affiliations
Sofia Khabirova
Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia
Gleb Aleshin
Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia
Tatiana Plakhova
Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia
Anastasia Zubenko
N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia
Anna Shchukina
N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia
Olga Fedorova
N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Vavilova, 28, GSP-1, 119991 Moscow, Russia
Aleksey Averin
Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of Sciences, Leninskiy Ave. 31b4, 119991 Moscow, Russia
Ekaterina Belova
Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia
Elena Bazarkina
The Rossendorf Beamline at ESRF—The European Synchrotron, CS40220, CEDEX 9, 38043 Grenoble, France
Kristina Kvashnina
The Rossendorf Beamline at ESRF—The European Synchrotron, CS40220, CEDEX 9, 38043 Grenoble, France
Stepan Kalmykov
Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia
DOI
https://doi.org/10.3390/nano12244484
Journal volume & issue
Vol. 12,
no. 24
Abstract
Read online
This study is one of the first attempts to assess CeO2 nanoparticles as a nanoplatform for radiopharmaceuticals with radionuclides. The process of functionalization using a bifunctional azacrown ligand is described, and the resulting conjugates are characterized by IR and Raman spectroscopy. Their complexes with 207Bi show a high stability in medically relevant media, thus encouraging the further study of these conjugates in vivo as potential combined radiopharmaceuticals.
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