Nature Communications (Apr 2020)
Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer
- Rosario I. Corona,
- Ji-Heui Seo,
- Xianzhi Lin,
- Dennis J. Hazelett,
- Jessica Reddy,
- Marcos A. S. Fonseca,
- Forough Abassi,
- Yvonne G. Lin,
- Paulette Y. Mhawech-Fauceglia,
- Sohrab P. Shah,
- David G. Huntsman,
- Alexander Gusev,
- Beth Y. Karlan,
- Benjamin P. Berman,
- Matthew L. Freedman,
- Simon A. Gayther,
- Kate Lawrenson
Affiliations
- Rosario I. Corona
- Cedars-Sinai Women’s Cancer Program at the Samuel Oschin Cancer Center
- Ji-Heui Seo
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Xianzhi Lin
- Cedars-Sinai Women’s Cancer Program at the Samuel Oschin Cancer Center
- Dennis J. Hazelett
- Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center
- Jessica Reddy
- Cedars-Sinai Women’s Cancer Program at the Samuel Oschin Cancer Center
- Marcos A. S. Fonseca
- Cedars-Sinai Women’s Cancer Program at the Samuel Oschin Cancer Center
- Forough Abassi
- Cedars-Sinai Women’s Cancer Program at the Samuel Oschin Cancer Center
- Yvonne G. Lin
- Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California
- Paulette Y. Mhawech-Fauceglia
- Department of Pathology, University of Southern California
- Sohrab P. Shah
- Department of Computer Science, University of British Columbia
- David G. Huntsman
- Department of Molecular Oncology, BC Cancer Agency
- Alexander Gusev
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Beth Y. Karlan
- Cedars-Sinai Women’s Cancer Program at the Samuel Oschin Cancer Center
- Benjamin P. Berman
- Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center
- Matthew L. Freedman
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Simon A. Gayther
- Cedars-Sinai Women’s Cancer Program at the Samuel Oschin Cancer Center
- Kate Lawrenson
- Cedars-Sinai Women’s Cancer Program at the Samuel Oschin Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-15951-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The role of non-coding somatic mutations in ovarian cancer is unclear. Here, the authors integrate genomic and epigenomic data from patient samples to show that these mutations frequently converge on the PAX8 transcriptional network.
