Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14

Ming Wang; Zhenhui Zhong; Javier Gallego-Bartolomé; Suhua Feng; Yuan-Hsin Shih; Mukun Liu; Jessica Zhou; John Curtis Richey; Charmaine Ng; Yasaman Jami-Alahmadi; James Wohlschlegel; Keqiang Wu; Steven E. Jacobsen

doi:10.1038/s41467-023-37263-9

Nature Communications (Mar 2023)

Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14

Ming Wang,
Zhenhui Zhong,
Javier Gallego-Bartolomé,
Suhua Feng,
Yuan-Hsin Shih,
Mukun Liu,
Jessica Zhou,
John Curtis Richey,
Charmaine Ng,
Yasaman Jami-Alahmadi,
James Wohlschlegel,
Keqiang Wu,
Steven E. Jacobsen

Affiliations

Ming Wang: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Zhenhui Zhong: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Javier Gallego-Bartolomé: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Suhua Feng: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Yuan-Hsin Shih: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Mukun Liu: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Jessica Zhou: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
John Curtis Richey: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Charmaine Ng: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles
Yasaman Jami-Alahmadi: Department of Biological Chemistry, University of California at Los Angeles
James Wohlschlegel: Department of Biological Chemistry, University of California at Los Angeles
Keqiang Wu: Institute of Plant Biology, National Taiwan University
Steven E. Jacobsen: Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles

DOI: https://doi.org/10.1038/s41467-023-37263-9
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

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TRB proteins have been shown to recruit PRC2 for H3K27me3 deposition. This work shows that TRBs also recruit JMJ14 to remove H3K4me3, demonstrating that TRBs silence the target genes via a combinatorial histone modification mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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