Nature Communications (Nov 2017)
Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia
- Martin Moder,
- Georgia Velimezi,
- Michel Owusu,
- Abdelghani Mazouzi,
- Marc Wiedner,
- Joana Ferreira da Silva,
- Lydia Robinson-Garcia,
- Fiorella Schischlik,
- Rastislav Slavkovsky,
- Robert Kralovics,
- Michael Schuster,
- Christoph Bock,
- Trey Ideker,
- Stephen P. Jackson,
- Jörg Menche,
- Joanna I. Loizou
Affiliations
- Martin Moder
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Georgia Velimezi
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Michel Owusu
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Abdelghani Mazouzi
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Marc Wiedner
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Joana Ferreira da Silva
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Lydia Robinson-Garcia
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Fiorella Schischlik
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Rastislav Slavkovsky
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Robert Kralovics
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Michael Schuster
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Christoph Bock
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Trey Ideker
- Department of Medicine, Division of Genetics, University of California San Diego
- Stephen P. Jackson
- The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Biochemistry, University of Cambridge
- Jörg Menche
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Joanna I. Loizou
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-017-01439-x
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 8
Abstract
Fanconi anemia is a complex disease affecting multiple DNA repair proteins that resolve DNA crosslinks which can block vital processes. Here the authors use parallel genome-wide screens that identify the BLM helicase complex as a suppressor of Fanconi anemia phenotypes.
