Evolution of design approaches in asymmetric organocatalysis over the last decade

Abstract

This perspective intends to cover the vast field of asymmetric organocatalysis and its evolution during the last ten years. This work has evaluated the corresponding timeline of the progression of the field concerning the main synthetic approaches as well as the ground-breaking synergetic approach between experimental and computational methods. With the combination of an evolutionary trend and the expansion of computing technology, further advancements in the field of asymmetric organocatalysis are undeniable.

Keywords

• Organocatalysis
• Computational chemistry
• Non-covalent interactions
• Asymmetric organocatalysis
• Catalyst design