Nature Communications (Jan 2023)
Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
- Cian McCafferty,
- Benjamin F. Gruenbaum,
- Renee Tung,
- Jing-Jing Li,
- Xinyuan Zheng,
- Peter Salvino,
- Peter Vincent,
- Zachary Kratochvil,
- Jun Hwan Ryu,
- Aya Khalaf,
- Kohl Swift,
- Rashid Akbari,
- Wasif Islam,
- Prince Antwi,
- Emily A. Johnson,
- Petr Vitkovskiy,
- James Sampognaro,
- Isaac G. Freedman,
- Adam Kundishora,
- Antoine Depaulis,
- François David,
- Vincenzo Crunelli,
- Basavaraju G. Sanganahalli,
- Peter Herman,
- Fahmeed Hyder,
- Hal Blumenfeld
Affiliations
- Cian McCafferty
- Department of Neurology, Yale School of Medicine
- Benjamin F. Gruenbaum
- Department of Neurology, Yale School of Medicine
- Renee Tung
- Department of Neurology, Yale School of Medicine
- Jing-Jing Li
- Department of Neurology, Yale School of Medicine
- Xinyuan Zheng
- Department of Neurology, Yale School of Medicine
- Peter Salvino
- Department of Neurology, Yale School of Medicine
- Peter Vincent
- Department of Neurology, Yale School of Medicine
- Zachary Kratochvil
- Department of Neurology, Yale School of Medicine
- Jun Hwan Ryu
- Department of Neurology, Yale School of Medicine
- Aya Khalaf
- Department of Neurology, Yale School of Medicine
- Kohl Swift
- Department of Neurology, Yale School of Medicine
- Rashid Akbari
- Department of Neurology, Yale School of Medicine
- Wasif Islam
- Department of Neurology, Yale School of Medicine
- Prince Antwi
- Department of Neurology, Yale School of Medicine
- Emily A. Johnson
- Department of Neurology, Yale School of Medicine
- Petr Vitkovskiy
- Department of Neurology, Yale School of Medicine
- James Sampognaro
- Department of Neurology, Yale School of Medicine
- Isaac G. Freedman
- Department of Neurology, Yale School of Medicine
- Adam Kundishora
- Department of Neurology, Yale School of Medicine
- Antoine Depaulis
- Univ. Grenoble Alpes, Inserm, U1216, Grenoble Institut Neurosciences
- François David
- Neuroscience Division, School of Bioscience, Cardiff University
- Vincenzo Crunelli
- Neuroscience Division, School of Bioscience, Cardiff University
- Basavaraju G. Sanganahalli
- Magnetic Resonance Research Center, Yale University
- Peter Herman
- Magnetic Resonance Research Center, Yale University
- Fahmeed Hyder
- Magnetic Resonance Research Center, Yale University
- Hal Blumenfeld
- Department of Neurology, Yale School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-35535-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
Absence seizures impair consciousness by an unknown neuronal mechanism. Here, the authors find that a rat absence seizure model’s behavior and hemodynamics recapitulate previously reported characteristics of human absence seizures, and uncover four distinct patterns of neuronal activity in cortex and thalamus during consciousness-impairing seizures.
