The multi-functional roles of forkhead box protein O in skin aging and diseases
Kyoung Mi Moon,
Min-Kyeong Lee,
Taehyeok Hwang,
Chun Whan Choi,
Min Soo Kim,
Hyeung-Rak Kim,
Bonggi Lee
Affiliations
Kyoung Mi Moon
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Republic of Korea
Min-Kyeong Lee
Department of Food Science and Nutrition, Pukyong National University, Nam-Gu, Busan, Republic of Korea
Taehyeok Hwang
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Republic of Korea
Chun Whan Choi
Natural Product Research Team, Biocenter, Gyeonggido Business and Science Accelerator, Gyeonggi-Do, Republic of Korea
Min Soo Kim
Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, Seoul, 02792, Republic of Korea
Hyeung-Rak Kim
Department of Food Science and Nutrition, Pukyong National University, Nam-Gu, Busan, Republic of Korea
Bonggi Lee
Department of Food Science and Nutrition, Pukyong National University, Nam-Gu, Busan, Republic of Korea; Corresponding author. Department of Food Science and Nutrition, Pukyong National University, Nam-Gu, Daeyeondong, Busan, Republic of Korea.
Forkhead box, class O (FoxO) family members are multifunctional transcription factors that are involved in several metabolic processes, including energy metabolism, apoptosis, DNA repair, and oxidative stress. However, their roles in skin health have not been well-documented. Recent studies have indicated that FoxOs are important factors to control skin homeostasis and health. The activation or deactivation of some FoxO family members is closely related to melanogenesis, wound healing, acne, and melanoma. In this review, we have discussed the recent findings that demonstrate the relationship between FoxOs and skin health as well as the underlying mechanisms associated with their functions.
