Current Chemistry Letters (Jan 2021)

Amidoalkylation of heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]- 2'-chloroacetamide and antimicrobial activity of derivatives

  • Turdibek Toshmurodov,
  • Abdukhakim Ziyaev,
  • Sobirdjan Sasmakov,
  • Jaloliddin Abdurakhmanov,
  • Mavluda Ziyaeva,
  • Dilnoza Ismailova,
  • Shakhnoz Azimova

DOI
https://doi.org/10.5267/j.ccl.2021.5.002
Journal volume & issue
Vol. 10, no. 4
pp. 427 – 434

Abstract

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Amidoalkylation of secondary heterocyclic amines by N-[5-(alkylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-chloroacetamide resulted the new compounds 5-10 that contain 1,3,4-thiadiazole-5-thione moiety alongside pyperidine, morpholine, and cytisine fragments. In vitro screening of antimicrobial activity of synthesized compounds showed that N-[5-(amylsulfanyl)-1,3,4-thiadiazol-2-yl]-2'-morpholinacetamide exhibited an appreciable antibacterial activity against gram-negative bacteria of Escherichia coli (inhibition zone diameter of 16 mm) and gram-positive bacteria of Staphylococcus aureus and Bacillus subtilis (10-13 mm).