Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

Rasheduzzaman Chowdhury; Ivanhoe K. H. Leung; Ya-Min Tian; Martine I. Abboud; Wei Ge; Carmen Domene; François-Xavier Cantrelle; Isabelle Landrieu; Adam P. Hardy; Christopher W. Pugh; Peter J. Ratcliffe; Timothy D. W. Claridge; Christopher J. Schofield

doi:10.1038/ncomms12673

Nature Communications (Aug 2016)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases

Rasheduzzaman Chowdhury,
Ivanhoe K. H. Leung,
Ya-Min Tian,
Martine I. Abboud,
Wei Ge,
Carmen Domene,
François-Xavier Cantrelle,
Isabelle Landrieu,
Adam P. Hardy,
Christopher W. Pugh,
Peter J. Ratcliffe,
Timothy D. W. Claridge,
Christopher J. Schofield

Affiliations

Rasheduzzaman Chowdhury: Department of Chemistry, Chemistry Research Laboratory, Oxford Centre for Integrative Systems Biology, University of Oxford
Ivanhoe K. H. Leung: Department of Chemistry, Chemistry Research Laboratory, Oxford Centre for Integrative Systems Biology, University of Oxford
Ya-Min Tian: Nuffield Department of Clinical Medicine, University of Oxford
Martine I. Abboud: Department of Chemistry, Chemistry Research Laboratory, Oxford Centre for Integrative Systems Biology, University of Oxford
Wei Ge: Department of Chemistry, Chemistry Research Laboratory, Oxford Centre for Integrative Systems Biology, University of Oxford
Carmen Domene: Department of Chemistry, Chemistry Research Laboratory, Oxford Centre for Integrative Systems Biology, University of Oxford
François-Xavier Cantrelle: UMR8576 CNRS-Lille University
Isabelle Landrieu: UMR8576 CNRS-Lille University
Adam P. Hardy: Department of Chemistry, Chemistry Research Laboratory, Oxford Centre for Integrative Systems Biology, University of Oxford
Christopher W. Pugh: Nuffield Department of Clinical Medicine, University of Oxford
Peter J. Ratcliffe: Nuffield Department of Clinical Medicine, University of Oxford
Timothy D. W. Claridge: Department of Chemistry, Chemistry Research Laboratory, Oxford Centre for Integrative Systems Biology, University of Oxford
Christopher J. Schofield: Department of Chemistry, Chemistry Research Laboratory, Oxford Centre for Integrative Systems Biology, University of Oxford

DOI: https://doi.org/10.1038/ncomms12673
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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The response to hypoxia involves multiple genes regulated by the hypoxia inducible transcription factors (HIFs), whose stability is regulated by prolyl hydroxylation. Here the authors provide a molecular basis for the substrate selectivity of the HIF prolyl hydroxylases that can be altered in erythrocytosis and cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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