Frontiers in Neurology (Apr 2020)

The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates

  • Andrea Horta-Barba,
  • Andrea Horta-Barba,
  • Andrea Horta-Barba,
  • Andrea Horta-Barba,
  • Javier Pagonabarraga,
  • Javier Pagonabarraga,
  • Javier Pagonabarraga,
  • Javier Pagonabarraga,
  • Saül Martínez-Horta,
  • Saül Martínez-Horta,
  • Saül Martínez-Horta,
  • Saül Martínez-Horta,
  • Juan Marín-Lahoz,
  • Juan Marín-Lahoz,
  • Juan Marín-Lahoz,
  • Frederic Sampedro,
  • Frederic Sampedro,
  • Frederic Sampedro,
  • Ramón Fernández-Bobadilla,
  • Ramón Fernández-Bobadilla,
  • M. Ángeles Botí,
  • M. Ángeles Botí,
  • Helena Bejr-Kasem,
  • Helena Bejr-Kasem,
  • Helena Bejr-Kasem,
  • Ignacio Aracil-Bolaños,
  • Ignacio Aracil-Bolaños,
  • Jesus Pérez-Pérez,
  • Jesus Pérez-Pérez,
  • Jesus Pérez-Pérez,
  • Berta Pascual-Sedano,
  • Berta Pascual-Sedano,
  • Berta Pascual-Sedano,
  • Antonia Campolongo,
  • Antonia Campolongo,
  • Cristina Izquierdo,
  • Beatriz Gómez-Ansón,
  • Beatriz Gómez-Ansón,
  • Beatriz Gómez-Ansón,
  • Jaime Kulisevsky,
  • Jaime Kulisevsky,
  • Jaime Kulisevsky,
  • Jaime Kulisevsky

DOI
https://doi.org/10.3389/fneur.2020.00240
Journal volume & issue
Vol. 11

Abstract

Read online

Introduction: Memory alterations are common in Parkinson's disease (PD) patients but the mechanisms involved in these deficits remain poorly understood. The study aims to explore the profile of episodic memory deficits in non-demented early PD patients.Methods: We obtained neurological, cognitive and behavioral data from 114 PD patients and 41 healthy controls (HC). PD participants were grouped as normal cognition (PD-NC) and mild cognitive impairment (PD-MCI) according to the Level II criteria of the Movement Disorders Society Task Force (MDS-TF). We evaluate the performance amongst groups on an episodic memory task using the Free and Cued Selective Reminding Test (FCSRT). Additionally, gray matter volume (GMV) voxel based morphometry, and mean diffusivity (MD) analyses were conducted in a subset of patients to explore the structural brain correlates of FCSRT performance.Results: Performance on all subscores of the FCSRT was significantly worse in PD-MCI than in PD-NC and HC. Delayed total recall (DTR) subscore was the best at differentiating PD-NC from PD-MCI. Using crosstabulation, DTR allowed identification of PD-MCI patients with an accuracy of 80%. Delayed free and cued recall was associated with decreased GMV and increased MD in multiple fronto-temporal and parietal areas.Conclusion: Encoding and retrieval deficits are a main characteristic of PD-MCI and are associated with structural damage in temporal, parietal and prefrontal areas.

Keywords