Clinical and Molecular Allergy (Dec 2021)
Quality of life in patients with allergic and immunologic skin diseases: in the eye of the beholder
- Ester Di Agosta,
- Lorenzo Salvati,
- Monica Corazza,
- Ilaria Baiardini,
- Francesca Ambrogio,
- Luisa Angileri,
- Elettra Antonelli,
- Federica Belluzzo,
- Domenico Bonamonte,
- Laura Bonzano,
- Raffaele Brancaccio,
- Paolo Custurone,
- Aurora De Marco,
- Aikaterini Detoraki,
- Adriana Di Guida,
- Elisabetta Di Leo,
- Marta Fantò,
- Filippo Fassio,
- Silvia Mariel Ferrucci,
- Caterina Foti,
- Rosella Gallo,
- Alessia Gatta,
- Fabrizio Guarneri,
- Lucia Guidolin,
- Katharina Hansel,
- Donatella Lamacchia,
- Carla Lombardo,
- Paola Lucia Minciullo,
- Maddalena Napolitano,
- Alessandro Pannofino,
- Andrea Paravisi,
- Roberta Parente,
- Maria Passante,
- Cataldo Patruno,
- Diego Peroni,
- Cristina Quecchia,
- Natale Schettini,
- Giuseppe Spadaro,
- Luca Stingeni,
- Daniele Tarrini,
- Marta Tramontana,
- Eustachio Nettis,
- Oliviero Rossi
Affiliations
- Ester Di Agosta
- Department of Experimental and Clinical Medicine, University of Florence
- Lorenzo Salvati
- Department of Experimental and Clinical Medicine, University of Florence
- Monica Corazza
- Section of Dermatology and Infectious Diseases, Department of Medical Sciences, University of Ferrara
- Ilaria Baiardini
- Respiratory Unit for Continuity of Care, IRCCS Ospedale Policlinico San Martino, Department of Internal Medicine (DiMI), University of Genoa
- Francesca Ambrogio
- Department of Biomedical Science and Human Oncology, Section of Dermatology, University of Bari
- Luisa Angileri
- Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
- Elettra Antonelli
- Section of Dermatology, Department of Medicine and Surgery, University of Perugia
- Federica Belluzzo
- ASP Trapani
- Domenico Bonamonte
- Department of Biomedical Sciences and Human Oncology, Section of Dermatology, University of Bari
- Laura Bonzano
- Dermatology Unit, Azienda USL – IRCCS di Reggio Emilia
- Raffaele Brancaccio
- Division of Allergy and Clinical Immunology, “Santa Maria Della Speranza” Hospital
- Paolo Custurone
- Section of Dermatology, Department of Clinical and Experimental Medicine, University of Messina
- Aurora De Marco
- Department of Biomedical Sciences and Human Oncology, Section of Dermatology, University of Bari
- Aikaterini Detoraki
- Department of Internal Medicine, Clinical Immunology, Clinical Pathology and Infectious Disease, Azienda Ospedaliera Universitaria Federico II
- Adriana Di Guida
- Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II
- Elisabetta Di Leo
- Section of Allergy and Clinical Immunology, Unit of Internal Medicine-“F. Miulli” Hospital
- Marta Fantò
- Unit of Allergology, Department of Dermatology, Policlinico Umberto I, Hospital-University Sapienza of Rome
- Filippo Fassio
- Allergy and Clinical Immunology Unit, San Giovanni di Dio Hospital
- Silvia Mariel Ferrucci
- Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico
- Caterina Foti
- Department of Biomedical Science and Human Oncology, Section of Dermatology, University of Bari
- Rosella Gallo
- Section of Dermatology - Department of Health Sciences, University of Genoa, Ospedale Policlinico San Martino - IRCCS
- Alessia Gatta
- Department of Medicine and Science of Ageing, G. d’Annunzio University
- Fabrizio Guarneri
- Section of Dermatology, Department of Clinical and Experimental Medicine, University of Messina
- Lucia Guidolin
- Allergy Unit, Department of Medicine, University of Verona
- Katharina Hansel
- Section of Dermatology, Department of Medicine and Surgery, University of Perugia
- Donatella Lamacchia
- Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital
- Carla Lombardo
- Allergy Unit, Villa Igea Hospital. A.P.S.S. Trento
- Paola Lucia Minciullo
- Department of Clinical and Experimental Medicine, School and Division of Allergy and Clinical Immunology, University Hospital ‘G. Martino’
- Maddalena Napolitano
- Department of Medicine and Health Science “V. Tiberio”, University of Molise
- Alessandro Pannofino
- Allergology and Immunology Clinic, Operative Unit of Medicine, Policoro Hospital
- Andrea Paravisi
- Section of Dermatology, Department of Health Sciences, University of Genoa, Ospedale Policlinico San Martino - IRCCS
- Roberta Parente
- Department of Medicine, Division of Allergy and Clinical Immunology, University of Salerno
- Maria Passante
- Department of Health Sciences, University Magna Graecia of Catanzaro
- Cataldo Patruno
- Department of Health Sciences, University Magna Graecia of Catanzaro
- Diego Peroni
- Section of Pediatrics, Department of Clinical and Experimental Medicine, University of Pisa
- Cristina Quecchia
- Io e l’Asma Center, Children’s Hospital, ASST Spedali Civili
- Natale Schettini
- Section of Dermatology and Infectious Diseases, Department of Medical Sciences, University of Ferrara
- Giuseppe Spadaro
- Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II
- Luca Stingeni
- Section of Dermatology, Department of Medicine and Surgery, University of Perugia
- Daniele Tarrini
- Allergy and Clinical Immunology Unit, Department of Clinical Medicine, Mauriziano Umberto I Hospital, University of Turin
- Marta Tramontana
- Section of Dermatology, Department of Medicine and Surgery, University of Perugia
- Eustachio Nettis
- Department of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari - Aldo Moro
- Oliviero Rossi
- Immunoallergology Unit, SOD Immunoallergologia, Azienda Ospedaliero-Universitaria Careggi
- DOI
- https://doi.org/10.1186/s12948-021-00165-6
- Journal volume & issue
-
Vol. 19,
no. 1
pp. 1 – 17
Abstract
Abstract Allergic and immunologic skin diseases negatively impact the quality of life (QoL) of affected patients with detrimental consequences. Nonetheless, in everyday clinical practice the evaluation of QoL is often overlooked. Considering the increasing prevalence of atopic dermatitis, allergic contact dermatitis, hereditary angioedema, cutaneous mastocytosis, and urticaria, it is essential to determine the effects of allergic and immunologic skin diseases on QoL. A joint meeting (GET TOGETHER 2021) of the Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC) and the Italian Society of Allergological, Occupational and Environmental Dermatology (SIDAPA) aimed to summarize the features of the main QoL tools used in these diseases and to describe the extent of QoL impairment as well as the impact of treatments on QoL, particularly biologic therapies. The assessment of QoL in patients with allergic and immunologic skin diseases relies on generic, organ-specific and disease-specific questionnaires. While generic and organ-specific questionnaires allow comparison between different diseases, disease-specific questionnaires are designed and validated for specific cohorts: the QoL Index for Atopic Dermatitis (QoLIAD) and the Childhood Atopic Dermatitis Impact Scale (CADIS) in atopic dermatitis, the ACD-11 in allergic contact dermatitis, the Angioedema QoL Questionnaire (AE-QoL) and the Hereditary Angioedema QoL questionnaire (HAE-QoL) in hereditary angioedema, the Mastocytosis QoL Questionnaires (MCQoL e MQLQ) in cutaneous mastocytosis, and the Chronic Urticaria QoL questionnaire (CU-Q2oL) in urticaria. Among the many factors that variably contribute to QoL impairment, pruritus can represent the leading cause of patient discomfort. Biologic therapies significantly ameliorate QoL in atopic dermatitis, hereditary angioedema, mastocytosis and chronic urticaria. In general, adequate management strategies are essential for improving QoL in patients with allergic and immunologic skin diseases.
Keywords
- Quality of life
- Atopic dermatitis
- Allergic contact dermatitis
- Hereditary angioedema
- Cutaneous mastocytosis
- Urticaria
