Molecular characterization of multiple myeloma

Abstract

Multiple myeloma (MM) is a hematologic malignancy that occurs when plasma cells, a type of white blood cell, grow out of control and start to overproduce antibodies that accumulates in blood and bone marrow. Despite the recent advance the survival rate for MM has not been increased significantly, which opens the need for identifying new molecular targets. This review article presents the most frequently observed gene mutations (KRAS (22.0%), NRAS (18.0%), DIS3 (9.3%), TTN (8.3%), ZNF717 (8.3%), TENT5C (7.3%), TP53 (7.3%) %), BRAF (6.3%), MUC16 (6.3%), RYR2 (5.4%), LRP1B (5.4%)) in MM patients and its rates, correlations, clinical significance, importance in the framework of MM disease and potential novel targets which are collected from the literature. The genes that are mutated in MM patients (211) taken from cBioportal data set. In conclusion, in the study conducted in MM patients, the 3 genes with the most frequent mutations were recorded as KRAS, NRAS and DIS3, respectively. In addition, in the context of our literature reviews and the data obtained, it appears that the TZNF717, TTN, MUC16, RYR2 genes need further study within the framework of MM.

Keywords

• multiple myeloma
• KRAS
• NRAS
• mutations