Nature Communications (Oct 2022)
Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs
- Liang Chen,
- Yucong Wang,
- Jiamei Lin,
- Zhenxing Song,
- Qinwei Wang,
- Wenfang Zhao,
- Yan Wang,
- Xiaoyu Xiu,
- Yuqi Deng,
- Xiuzhi Li,
- Qiqi Li,
- Xiaolin Wang,
- Jingxin Li,
- Xu Liu,
- Kunpeng Liu,
- Jincong Zhou,
- Kuan Li,
- Yuchan Liu,
- Shanhui Liao,
- Qin Deng,
- Chao Xu,
- Qianwen Sun,
- Shengzhou Wu,
- Kaiming Zhang,
- Min-Xin Guan,
- Tianhua Zhou,
- Fei Sun,
- Xiujun Cai,
- Chuan Huang,
- Ge Shan
Affiliations
- Liang Chen
- Department of Clinical Laboratory, The First Affiliated Hospital of USTC, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China
- Yucong Wang
- Department of Clinical Laboratory, The First Affiliated Hospital of USTC, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China
- Jiamei Lin
- School of Life Sciences, Chongqing University
- Zhenxing Song
- School of Life Sciences, Chongqing University
- Qinwei Wang
- Department of Clinical Laboratory, The First Affiliated Hospital of USTC, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China
- Wenfang Zhao
- Department of Clinical Laboratory, The First Affiliated Hospital of USTC, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China
- Yan Wang
- School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University
- Xiaoyu Xiu
- School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University
- Yuqi Deng
- Department of Clinical Laboratory, The First Affiliated Hospital of USTC, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China
- Xiuzhi Li
- Department of Clinical Laboratory, The First Affiliated Hospital of USTC, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China
- Qiqi Li
- Department of Clinical Laboratory, The First Affiliated Hospital of USTC, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China
- Xiaolin Wang
- Department of Clinical Laboratory, The First Affiliated Hospital of USTC, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China
- Jingxin Li
- Department of Clinical Laboratory, The First Affiliated Hospital of USTC, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China
- Xu Liu
- Department of Clinical Laboratory, The First Affiliated Hospital of USTC, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China
- Kunpeng Liu
- Center for Plant Biology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University
- Jincong Zhou
- Center for Plant Biology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University
- Kuan Li
- Center for Plant Biology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University
- Yuchan Liu
- MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China
- Shanhui Liao
- Division of Life Science and Medicine, CAS Key Laboratory of Structural Biology, University of Science and Technology of China
- Qin Deng
- Analytical and Testing Center, Chongqing University
- Chao Xu
- Division of Life Science and Medicine, CAS Key Laboratory of Structural Biology, University of Science and Technology of China
- Qianwen Sun
- Center for Plant Biology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University
- Shengzhou Wu
- School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou Medical University
- Kaiming Zhang
- MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Division of Life Sciences and Medicine, University of Science and Technology of China
- Min-Xin Guan
- The Children’s Hospital, Zhejiang University School of Medicine and National Clinical Research Center for Child Health, Zhejiang Provincial Key Lab of Genetic and Developmental Disorder, Institute of Genetics, Zhejiang University School of Medicine
- Tianhua Zhou
- Department of Cell Biology and Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Cancer Center, Institute of Gastroenterology, Zhejiang University
- Fei Sun
- Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine
- Xiujun Cai
- Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine
- Chuan Huang
- School of Life Sciences, Chongqing University
- Ge Shan
- Department of Clinical Laboratory, The First Affiliated Hospital of USTC, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China
- DOI
- https://doi.org/10.1038/s41467-022-33356-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
This study identifies the evolutionarily conserved Exportin 4 as an essential regulator in the nuclear export of circRNAs. Defective circRNA export results in R-loop formation and DNA damage in cells, as well as testis and neurological defects in mice.
