Nintedanib and intensive immunosuppressive therapy to treat rapidly progressive interstitial lung disease presenting anti-ARS antibodies

Toyoshi Yanagihara; Kunihiro Suzuki; Ayaka Egashira; Naruhiko Ogo; Tatsuma Asoh; Tsukasa Nara; Kensaku Takatsuki; Seiji Yoshizawa; Sy Giin Chong; Naoki Hamada; Takashige Maeyama

Respiratory Medicine Case Reports (Jan 2020)

Nintedanib and intensive immunosuppressive therapy to treat rapidly progressive interstitial lung disease presenting anti-ARS antibodies

Toyoshi Yanagihara,
Kunihiro Suzuki,
Ayaka Egashira,
Naruhiko Ogo,
Tatsuma Asoh,
Tsukasa Nara,
Kensaku Takatsuki,
Seiji Yoshizawa,
Sy Giin Chong,
Naoki Hamada,
Takashige Maeyama

Affiliations

Toyoshi Yanagihara: Department of Respiratory Medicine, And Department of Rheumatology, Hamanomachi Hospital, Fukuoka, 810-8539, Japan; Research Institute for Diseases of the Chest, Kyushu University, Fukuoka, 812-8582, Japan; Corresponding author. Department of Respiratory Medicine, and Department of Rheumatology, Hamanomachi Hospital, Fukuoka, 810-8539, Japan.
Kunihiro Suzuki: Research Institute for Diseases of the Chest, Kyushu University, Fukuoka, 812-8582, Japan
Ayaka Egashira: Department of Respiratory Medicine, And Department of Rheumatology, Hamanomachi Hospital, Fukuoka, 810-8539, Japan
Naruhiko Ogo: Department of Respiratory Medicine, And Department of Rheumatology, Hamanomachi Hospital, Fukuoka, 810-8539, Japan
Tatsuma Asoh: Department of Respiratory Medicine, And Department of Rheumatology, Hamanomachi Hospital, Fukuoka, 810-8539, Japan
Tsukasa Nara: Department of Respiratory Medicine, And Department of Rheumatology, Hamanomachi Hospital, Fukuoka, 810-8539, Japan
Kensaku Takatsuki: Department of Rheumatology, Hamanomachi Hospital, Fukuoka, 810-8539, Japan
Seiji Yoshizawa: Department of Rheumatology, Hamanomachi Hospital, Fukuoka, 810-8539, Japan
Sy Giin Chong: Firestone Institute for Respiratory Health, Research Institute at St Joseph's Healthcare, Department of Medicine, McMaster University, Hamilton, ON, Canada
Naoki Hamada: Research Institute for Diseases of the Chest, Kyushu University, Fukuoka, 812-8582, Japan
Takashige Maeyama: Department of Respiratory Medicine, And Department of Rheumatology, Hamanomachi Hospital, Fukuoka, 810-8539, Japan

Journal volume & issue: Vol. 31
p. 101272

Abstract

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We describe a case of fulminant onset, rapidly progressive-interstitial lung disease (RP-ILD) with anti-ARS antibodies (anti-PL-7). The patient was successfully treated with nintedanib in addition to intensive immunosuppressive therapies, including intravenous cyclophosphamide. Nintedanib has just been approved for treatment of progressive fibrosing ILD, but to date, no reports of RP-ILD treated with nintedanib have been published. This case report may advance discussions regarding the use and timing of nintedanib in treating RP-ILD.

Published in Respiratory Medicine Case Reports

ISSN: 2213-0071 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: http://www.journals.elsevier.com/respiratory-medicine-case-reports/

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