Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration

Hao Zhou; Jinpeng He; Renfeng Liu; Jun Cheng; Yuhao Yuan; Wanpu Mao; Jun Zhou; Honghui He; Qianqi Liu; Wei Tan; Cijun Shuai; Youwen Deng

Bioactive Materials (Jul 2024)

Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration

Hao Zhou,
Jinpeng He,
Renfeng Liu,
Jun Cheng,
Yuhao Yuan,
Wanpu Mao,
Jun Zhou,
Honghui He,
Qianqi Liu,
Wei Tan,
Cijun Shuai,
Youwen Deng

Affiliations

Hao Zhou: Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China; Department of Joint Surgery and Sports Medicine, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421002, China
Jinpeng He: Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Renfeng Liu: Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Jun Cheng: Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Yuhao Yuan: Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China
Wanpu Mao: Department of Joint Surgery and Sports Medicine, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421002, China
Jun Zhou: Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China
Honghui He: Department of Joint Surgery and Sports Medicine, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421002, China
Qianqi Liu: Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
Wei Tan: Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China; Corresponding author. Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Cijun Shuai: State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha, 410083, China; Corresponding author. State Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha, Hunan, 410083, China.
Youwen Deng: Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China; Corresponding author. Department of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.

Journal volume & issue: Vol. 37
pp. 51 – 71

Abstract

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Intervertebral disc degeneration (IVDD) can be caused by aging, injury, and genetic factors. The pathological changes associated with IVDD include the excessive accumulation of reactive oxygen species (ROS), cellular pyroptosis, and extracellular matrix (ECM) degradation. There are currently no approved specific molecular therapies for IVDD. In this study, we developed a multifunctional and microenvironment-responsive metal-phenolic network release platform, termed TMP@Alg-PBA/PVA, which could treat (IL-1β)-induced IVDD. The metal-phenolic network (TA-Mn-PVP, TMP) released from this platform targeted mitochondria to efficiently scavenge ROS and reduce ECM degradation. Pyroptosis was suppressed through the inhibition of the IL-17/ERK signaling pathway. These findings demonstrate the versatility of the platform. And in a rat model of IVDD, TMP@Alg-PBA/PVA exhibited excellent therapeutic effects by reducing the progression of the disease. TMP@Alg-PBA/PVA, therefore, presents clinical potential for the treatment of IVDD.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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