Nature Communications (Dec 2022)
Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen
- Pengjie Hu,
- Hao Ding,
- Huimin Liu,
- Yulin Yang,
- Lei Chen,
- Guang-Jun He,
- Weixin Ke,
- Ping Zhu,
- Xiuyun Tian,
- Yan Peng,
- Zhenghao Shen,
- Xiaoxia Yao,
- Changyu Tao,
- Ence Yang,
- Guojian Liao,
- Xiao Liu,
- Linqi Wang
Affiliations
- Pengjie Hu
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
- Hao Ding
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
- Huimin Liu
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
- Yulin Yang
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
- Lei Chen
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
- Guang-Jun He
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
- Weixin Ke
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
- Ping Zhu
- The Medical Research Institute, College of Pharmaceutical Sciences, Southwest University
- Xiuyun Tian
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
- Yan Peng
- The Medical Research Institute, College of Pharmaceutical Sciences, Southwest University
- Zhenghao Shen
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
- Xiaoxia Yao
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
- Changyu Tao
- Department of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center
- Ence Yang
- Department of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center
- Guojian Liao
- The Medical Research Institute, College of Pharmaceutical Sciences, Southwest University
- Xiao Liu
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
- Linqi Wang
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-022-35549-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Pathogenic fungi of the genus Cryptococcus can undergo bisexual and unisexual reproduction. Here, the authors construct a gene-deletion library for over 100 transcription factor genes in Cryptococcus deneoformans and provide insights into regulatory cascades that are specific for each reproductive mode.
