Data and experimental setup for a comprehensive study of ketamine's effect on neuronal plasticity following social isolation rearing in male and female rats

Abstract

In this study, we collected electrophysiological data from acute hippocampal slices of male and female Sprague Dawley rats. Rats were exposed to social isolation rearing and then acutely treated with various doses of ketamine in order to rescue hippocampal plasticity deficits induced by isolation stress. We used two different approaches to study neuronal plasticity: Long-Term Potentiation (LTP) which is a well-established cellular model for memory and Paired-Pulse Facilitation (PPF) which is short-term of presynaptic plasticity. The aim of this article is to offer more experimental details about out LTP and PPF procedures.

Keywords

• Social isolation
• Ketamine
• Long term potentiation
• Paired pulse facilitation
• Hippocampus
• Plasticity