Nature Communications (Jan 2019)
A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies
- Yuanbin Song,
- Anthony Rongvaux,
- Ashley Taylor,
- Tingting Jiang,
- Toma Tebaldi,
- Kunthavai Balasubramanian,
- Arun Bagale,
- Yunus Kasim Terzi,
- Rana Gbyli,
- Xiaman Wang,
- Xiaoying Fu,
- Yimeng Gao,
- Jun Zhao,
- Nikolai Podoltsev,
- Mina Xu,
- Natalia Neparidze,
- Ellice Wong,
- Richard Torres,
- Emanuela M. Bruscia,
- Yuval Kluger,
- Markus G. Manz,
- Richard A. Flavell,
- Stephanie Halene
Affiliations
- Yuanbin Song
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- Anthony Rongvaux
- Department of Immunobiology, Yale University School of Medicine
- Ashley Taylor
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- Tingting Jiang
- Department of Pathology, Yale University School of Medicine
- Toma Tebaldi
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- Kunthavai Balasubramanian
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- Arun Bagale
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- Yunus Kasim Terzi
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- Rana Gbyli
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- Xiaman Wang
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- Xiaoying Fu
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- Yimeng Gao
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- Jun Zhao
- Department of Pathology, Yale University School of Medicine
- Nikolai Podoltsev
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- Mina Xu
- Department of Pathology, Yale University School of Medicine
- Natalia Neparidze
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- Ellice Wong
- Section of Hematology/Oncology, VA Medical Center
- Richard Torres
- Department of Laboratory Medicine, Yale University School of Medicine
- Emanuela M. Bruscia
- Department of Pediatrics, Yale University School of Medicine
- Yuval Kluger
- Department of Pathology, Yale University School of Medicine
- Markus G. Manz
- Hematology, University Hospital and University of Zurich
- Richard A. Flavell
- Department of Immunobiology, Yale University School of Medicine
- Stephanie Halene
- Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-08166-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Myelodyplastic hematopoietic stem cells (MDS HSC) have eluded in vivo modeling. Here the authors present a highly efficient MDS patient-derived xenotransplantation model in cytokine-humanized mice with replication of the donors’ genetic complexity and myeloid, erythroid, and megakaryocytic lineage dysplasia.
