Cholinesterase inhibitory activity and chemical constituents of Stenochlaena palustris fronds at two different stages of maturity

Journal of Food and Drug Analysis. 2016;24(2):358-366 DOI 10.1016/j.jfda.2015.12.005

 

Journal Homepage

Journal Title: Journal of Food and Drug Analysis

ISSN: 1021-9498 (Print)

Publisher: Elsevier

Society/Institution: Food and Drug Administration of Taiwan

LCC Subject Category: Technology: Home economics: Nutrition. Foods and food supply | Medicine: Therapeutics. Pharmacology

Country of publisher: Taiwan, Province of China

Language of fulltext: English

Full-text formats available: PDF, HTML

 

AUTHORS

Nelson Jeng-Yeou Chear (Centre for Drug Research, Universiti Sains Malaysia, Penang, Malaysia)
Kooi-Yeong Khaw (School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia)
Vikneswaran Murugaiyah (School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia)
Choon-Sheen Lai (Centre for Drug Research, Universiti Sains Malaysia, Penang, Malaysia)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 6 weeks

 

Abstract | Full Text

Stenochlaena palustris fronds are popular as a vegetable in Southeast Asia. The objectives of this study were to evaluate the anticholinesterase properties and phytochemical profiles of the young and mature fronds of this plant. Both types of fronds were found to have selective inhibitory effect against butyrylcholinesterase compared with acetylcholinesterase. However, different sets of compounds were responsible for their activity. In young fronds, an antibutyrylcholinesterase effect was observed in the hexane extract, which was comprised of a variety of aliphatic hydrocarbons, fatty acids, and phytosterols. In the mature fronds, inhibitory activity was observed in the methanol extract, which contained a series of kaempferol glycosides. Our results provided novel information concerning the ability of S. palustris to inhibit cholinesterase and its phytochemical profile. Further research to investigate the potential use of this plant against Alzheimer's disease is warranted, however, young and mature fronds should be distinguished due to their phytochemical differences.