miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression

Paul N. Valdmanis; Hak Kyun Kim; Kirk Chu; Feijie Zhang; Jianpeng Xu; Elizabeth M. Munding; Jia Shen; Mark A. Kay

doi:10.1038/s41467-018-07786-7

Nature Communications (Dec 2018)

miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression

Paul N. Valdmanis,
Hak Kyun Kim,
Kirk Chu,
Feijie Zhang,
Jianpeng Xu,
Elizabeth M. Munding,
Jia Shen,
Mark A. Kay

Affiliations

Paul N. Valdmanis: Department of Pediatrics, Stanford University
Hak Kyun Kim: Department of Pediatrics, Stanford University
Kirk Chu: Department of Pediatrics, Stanford University
Feijie Zhang: Department of Pediatrics, Stanford University
Jianpeng Xu: Department of Pediatrics, Stanford University
Elizabeth M. Munding: Department of Pediatrics, Stanford University
Jia Shen: Department of Pediatrics, Stanford University
Mark A. Kay: Department of Pediatrics, Stanford University

DOI: https://doi.org/10.1038/s41467-018-07786-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

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miR-122 is a highly expressed microRNA in the liver. Here the authors analyse the mouse liver microRNA landscape following depletion of miR-122 and the impact that this has on its target mRNAs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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