Nature Communications (Jan 2023)

Kaposi’s sarcoma-associated herpesvirus induces specialised ribosomes to efficiently translate viral lytic mRNAs

  • James C. Murphy,
  • Elena M. Harrington,
  • Sophie Schumann,
  • Elton J. R. Vasconcelos,
  • Timothy J. Mottram,
  • Katherine L. Harper,
  • Julie L. Aspden,
  • Adrian Whitehouse

DOI
https://doi.org/10.1038/s41467-023-35914-5
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 15

Abstract

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Viruses rely on the translational machinery of the host cell to synthesis viral proteins. We show that KSHV manipulates the composition of host cell ribosomes creating a specialised ribosome to specifically translate viral mRNAs.