Emerging Infectious Diseases (Oct 2020)

Drug Resistance Spread in 6 Metropolitan Regions, Germany, 2001–2018

  • Melanie Stecher,
  • Antoine Chaillon,
  • Christoph Stephan,
  • Elena Knops,
  • Niko Kohmer,
  • Clara Lehmann,
  • Josef Eberle,
  • Johannes Bogner,
  • Christoph D. Spinner,
  • Anna Maria Eis-Hübinger,
  • Jan-Christian Wasmuth,
  • Guido Schäfer,
  • Georg Behrens,
  • Sanjay R. Mehta,
  • Jörg Janne Vehreschild,
  • Martin Hoenigl

DOI
https://doi.org/10.3201/eid2610.191506
Journal volume & issue
Vol. 26, no. 10
pp. 2439 – 2443

Abstract

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We analyzed 1,397 HIV-1 pol sequences of antiretroviral therapy–naive patients in a total of 7 university hospitals in Bonn, Cologne, Frankfurt, Hamburg, Hannover, and Munich, Germany. Phylogenetic and network analysis elucidated numerous cases of shared drug resistance mutations among genetically linked patients; K103N was the most frequently shared mutation.

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