Nature Communications (Jun 2020)
Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
- Therese Vu,
- Jasmin Straube,
- Amy H. Porter,
- Megan Bywater,
- Axia Song,
- Victoria Ling,
- Leanne Cooper,
- Gabor Pali,
- Claudia Bruedigam,
- Sebastien Jacquelin,
- Joanne Green,
- Graham Magor,
- Andrew Perkins,
- Alistair M. Chalk,
- Carl R. Walkley,
- Florian H. Heidel,
- Pamela Mukhopadhyay,
- Nicole Cloonan,
- Stefan Gröschel,
- Jan-Philipp Mallm,
- Stefan Fröhling,
- Claudia Scholl,
- Steven W. Lane
Affiliations
- Therese Vu
- Cancer Program, QIMR Berghofer Medical Research Institute
- Jasmin Straube
- Cancer Program, QIMR Berghofer Medical Research Institute
- Amy H. Porter
- Cancer Program, QIMR Berghofer Medical Research Institute
- Megan Bywater
- Cancer Program, QIMR Berghofer Medical Research Institute
- Axia Song
- Cancer Program, QIMR Berghofer Medical Research Institute
- Victoria Ling
- Cancer Program, QIMR Berghofer Medical Research Institute
- Leanne Cooper
- Cancer Program, QIMR Berghofer Medical Research Institute
- Gabor Pali
- Cancer Program, QIMR Berghofer Medical Research Institute
- Claudia Bruedigam
- Cancer Program, QIMR Berghofer Medical Research Institute
- Sebastien Jacquelin
- Cancer Program, QIMR Berghofer Medical Research Institute
- Joanne Green
- Cancer Program, QIMR Berghofer Medical Research Institute
- Graham Magor
- Australian Centre for Blood Diseases, Monash University
- Andrew Perkins
- Australian Centre for Blood Diseases, Monash University
- Alistair M. Chalk
- St. Vincent’s Institute
- Carl R. Walkley
- St. Vincent’s Institute
- Florian H. Heidel
- Leibniz-Institute on Aging—Fritz Lipmann Institute (FLI) and Innere Medizin 2, Hämatologie und Onkologie, Universitätsklinikum Jena
- Pamela Mukhopadhyay
- Cancer Program, QIMR Berghofer Medical Research Institute
- Nicole Cloonan
- Cancer Program, QIMR Berghofer Medical Research Institute
- Stefan Gröschel
- German Cancer Research Center
- Jan-Philipp Mallm
- German Cancer Research Center
- Stefan Fröhling
- German Cancer Research Center
- Claudia Scholl
- German Cancer Research Center
- Steven W. Lane
- Cancer Program, QIMR Berghofer Medical Research Institute
- DOI
- https://doi.org/10.1038/s41467-020-16840-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells in the majority of patients with leukemia but not during normal blood formation. Here, the authors report a mouse model with conditional Cdx2 expression showing de novo leukemic transformation, and use it to optimize treatment in high-risk AML.
