Вісник проблем біології і медицини (Dec 2020)

FEATURES OF THE COMPOSITION OF THE MICROFLORA OF THE GENITOURINARY TRACT IN WOMEN IN NORMAL AND PATHOGENESIS

  • Hospod V. V.,
  • Golodok L. P.,
  • Sklyar T. V.

DOI
https://doi.org/10.29254/2077-4214-2020-4-158-247-253
Journal volume & issue
no. 4
pp. 247 – 253

Abstract

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. Pathogens of dysbiotic disorders of the genitourinary tract in 80 women aged 19 to 55 years were isolated and identified in the Diagnostic Center of the Medical Academy of the city of Dnipro using the method of polymerase chain reaction. With this method, you can objectively and accurately assess the system of biocenosis of the vagina in a short time by quantitative and qualitative assessment of different groups of microorganisms and identify the relationship between them. It is shown that in the normocenosis the number of microorganisms is 105 -107 CFU/ ml. The number of members of the genus Lactobacillus spp. averages 107 CFU/ml, Gardnarella vaginalis, Megashera spp. – 104 CFU/ml, Enterobacteriaceae spp., Streptococcus spp., Staphylococcus spp., Peptostreptococcus spp., Atopobium vaginae, Ureaplasma spp., Candida sp. – 103 CFU/ml, however, in dysbiosis, the microbial composition of the urogenital tract is characterized by a decrease in the number of lactobacilli and their replacement by opportunistic anaerobic microorganisms. Such disorders can lead to bacterial vaginosis – 42%, nonspecific vaginitis – 30%, candidiasis – 25%, the association of bacterial vaginosis with nonspecific vaginitis 3%. At dysbiotic disturbances of microflora of urogenital tract in high concentrations representatives of Mobiluncus spp., Peptostreptococcus spp., Gardnerella vaginallis, Atopobium vaginallis, Enterobacteriaceae spp., Streptococcus spp., Staphylococcus spp. Spp., Velionella spp., Сandida spp. The main causes of the above dysbiotic disorders in these age groups are associated with endocrine disorders, stress, allergies, climate change, changes in local and general immune status (decreased circulating immune complexes, decreased Ig A, increased Ig G), unsystematic antibacterial therapy and reception hormonal drugs, contraceptive use, inflammatory diseases of the female genital organs, frequent change of sexual partners, surgical and diagnostic interventions, dysfunction and microbial status of the intestine.

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