PLoS ONE (Jan 2022)

Impact of histological subtype on prognosis in stage IV colorectal cancer: A population-based cohort study

  • Teppei Miyakawa,
  • Hidetaka Kawamura,
  • Michitaka Honda,
  • Yoshinao Takano,
  • Shunji Kinuta,
  • Takahiro Kamiga,
  • Shigeru Yamazaki,
  • Atsushi Muto,
  • Satoru Shiraso,
  • Naoyuki Yamashita,
  • Toshiyasu Iwao,
  • Koji Kono,
  • Shinichi Konno

Journal volume & issue
Vol. 17, no. 3

Abstract

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Background There are a few established prognostic factors for stage IV colorectal cancer. Thus, this study aimed to evaluate the impact of histological subtypes on prognosis and metastatic patterns in patients with stage IV colorectal cancer. Methods This was a population-based, multicenter, cohort study. We included consecutive patients diagnosed with stage IV colorectal cancer between 2008 and 2015 at all designated cancer hospitals in Fukushima prefecture, Japan. Patients were classified into two groups according to histological subtypes as follows: poorly differentiated adenocarcinoma (Por), mucinous adenocarcinoma (Muc), or signet-ring cell carcinoma (Sig) and well (Wel) or moderately differentiated adenocarcinoma (Mod). We evaluated the relationship between these histological groups and survival time. After adjusting for other clinical factors, we calculated the hazard ratio for Por/Muc/Sig. Results A total of 1,151 patients were enrolled, and 1,031 and 120 had Wel/Mod and Por/Muc/Sig, respectively. The median overall survival was 19.2 and 11.9 months for Wel/Mod and Por/Muc/Sig, respectively (p Conclusions The Por/Muc/Sig histological subtype was an independent prognostic factor for poor prognosis among patients with stage IV colorectal cancer. The histological subtype may be useful for predicting the prognosis of patients with stage IV colorectal cancer and designing the treatment strategy.