Chromosomal Abnormalities in Early Pregnancy Losses: A Study of 900 Samples

Abstract

Chromosomal abnormalities are the most common causes of early pregnancy losses (EPLs). In this study, we aimed to evaluate the incidence and spectrum of chromosomal abnormalities in EPLs and correlate them with different clinical characteristics. We performed Quantitative Fluorescent PCR (QF-PCR), followed by subtelomeric Multiplex Ligation Probe Amplification (MLPA) analysis to detect chromosomal abnormalities in 900 products of conceptions (POCs) from EPLs collected over a period of 10 years.

Keywords

• chromosomal abnormality
• early pregnancy loss (epl)
• qf-pcr
• mlpa