Communications Biology (Apr 2023)

LncAABR07053481 inhibits bone marrow mesenchymal stem cell apoptosis and promotes repair following steroid-induced avascular necrosis

  • Tao Wang,
  • Zhi-Hong Xie,
  • Lei Wang,
  • Hong Luo,
  • Jian Zhang,
  • Wen-Tao Dong,
  • Xiao-Han Zheng,
  • Chuan Ye,
  • Xiao-Bin Tian,
  • Gang Liu,
  • Xue-Song Zhu,
  • Yan-Lin Li,
  • Qing-Lin Kang,
  • Fei Zhang,
  • Wu-Xun Peng

DOI
https://doi.org/10.1038/s42003-023-04661-0
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 14

Abstract

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Long non-coding RNA AABR07053481 is shown to inhibit hypoxia-induced apoptosis of bone marrow mesenchymal stem cells in rats by regulating the miR-664-2-5p/Notch1 pathway, promote the repair efficacy of BMSCs on early steroid-induced avascular necrosis of the femoral head.