Effects of malathion nebulization on the histopathology of the respiratory tract of Wistar rats, treated with sublingual atropine sulfate eye drops

Abstract

This study sought to evaluate the histological damage to the respiratory tract caused by inhaling an aqueous solution of 50% malathion, as well as the protective effects of sublingually-applied 1% atropine sulfate eye drops in rats. We searched the literature for the signs and symptoms associated with malathion inhalation for rats, humans, and livestock. We divide 24 female Wistar rats into three groups exposed to distilled water, malathion, and plastic boxes coupled to nebulizers kept at 22– 24°C. At the end of the experiment, the mice were sacrificed and their lungs and trachea were harvested. Histopathological examination revealed that the trachea in the treatment group is similar to that of the control group.

Keywords

• sublingual atropine, intoxication, malathion, histopathology.