Redesigning regulatory components of quorum-sensing system for diverse metabolic control

Chang Ge; Zheng Yu; Huakang Sheng; Xiaolin Shen; Xinxiao Sun; Yifei Zhang; Yajun Yan; Jia Wang; Qipeng Yuan

doi:10.1038/s41467-022-29933-x

Nature Communications (Apr 2022)

Redesigning regulatory components of quorum-sensing system for diverse metabolic control

Chang Ge,
Zheng Yu,
Huakang Sheng,
Xiaolin Shen,
Xinxiao Sun,
Yifei Zhang,
Yajun Yan,
Jia Wang,
Qipeng Yuan

Affiliations

Chang Ge: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology
Zheng Yu: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology
Huakang Sheng: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology
Xiaolin Shen: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology
Xinxiao Sun: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology
Yifei Zhang: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology
Yajun Yan: School of Chemical, Materials, and Biomedical Engineering, College of Engineering, The University of Georgia
Jia Wang: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology
Qipeng Yuan: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology

DOI: https://doi.org/10.1038/s41467-022-29933-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Existing quorum sensing (QS) circuits are less sophisticated for regulating multiple sets of genes or operons. Here, the authors redesign the luxR-luxI intergenic sequence of the lux-type QS system and apply it to achieve diverse metabolic control in salicylic acid and 4-hydroxycoumarin biosynthesis in E. coli.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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