Nature Communications (Sep 2018)

High-resolution NMR studies of antibiotics in cellular membranes

  • João Medeiros-Silva,
  • Shehrazade Jekhmane,
  • Alessandra Lucini Paioni,
  • Katarzyna Gawarecka,
  • Marc Baldus,
  • Ewa Swiezewska,
  • Eefjan Breukink,
  • Markus Weingarth

DOI
https://doi.org/10.1038/s41467-018-06314-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Antibiotics that target the peptidoglycan precursor lipid II are promising templates for next-generation antibiotics. Here authors use solid-state NMR and monitor lipid II-binding antibiotics, such as nisin, directly in cell membranes.