Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity

Anja Waizenegger; Madhusoodanan Urulangodi; Carl P. Lehmann; Teresa Anne Clarisse Reyes; Irene Saugar; José Antonio Tercero; Barnabas Szakal; Dana Branzei

doi:10.1038/s41467-020-19503-4

Nature Communications (Nov 2020)

Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity

Anja Waizenegger,
Madhusoodanan Urulangodi,
Carl P. Lehmann,
Teresa Anne Clarisse Reyes,
Irene Saugar,
José Antonio Tercero,
Barnabas Szakal,
Dana Branzei

Affiliations

Anja Waizenegger: IFOM, the FIRC Institute of Molecular Oncology
Madhusoodanan Urulangodi: IFOM, the FIRC Institute of Molecular Oncology
Carl P. Lehmann: Centro de Biología Molecular Severo Ochoa (CSIC/UAM)
Teresa Anne Clarisse Reyes: IFOM, the FIRC Institute of Molecular Oncology
Irene Saugar: Centro de Biología Molecular Severo Ochoa (CSIC/UAM)
José Antonio Tercero: Centro de Biología Molecular Severo Ochoa (CSIC/UAM)
Barnabas Szakal: IFOM, the FIRC Institute of Molecular Oncology
Dana Branzei: IFOM, the FIRC Institute of Molecular Oncology

DOI: https://doi.org/10.1038/s41467-020-19503-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Mus81-Mms4 endonuclease is critical for processing various DNA recombination structures. Here the authors uncover a regulatory mechanism of the endonuclease via posttranslational modifications involving SUMOylation and ubiquitylation that impact on genome integrity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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