Frontiers in Pediatrics (Feb 2024)

Summary of biological research on hepatoblastoma: a scoping review

  • Huan-sheng Wang,
  • Jing Lao,
  • Ren-sen Jiang,
  • Bin Wang,
  • Xiao-peng Ma,
  • Jian-yao Wang

DOI
https://doi.org/10.3389/fped.2024.1309693
Journal volume & issue
Vol. 12

Abstract

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BackgroundHepatoblastoma is the most prevalent primary hepatic malignancy in children, comprising 80% of pediatric hepatic malignancies and 1% of all pediatric malignancies. However, traditional treatments have proven inadequate in effectively curing hepatoblastoma, leading to a poor prognosis.MethodsA literature search was conducted on multiple electronic databases (PubMed and Google Scholar). A total of 86 articles were eligible for inclusion in this review.ResultThis review aims to consolidate recent developments in hepatoblastoma research, focusing on the latest advances in cancer-associated genomics, epigenetic studies, transcriptional programs and molecular subtypes. We also discuss the current treatment approaches and forthcoming strategies to address cancer-associated biological challenges.ConclusionTo provide a comprehensive summary of the molecular mechanisms associated with hepatoblastoma occurrence, this review highlights three key aspects: genomics, epigenetics, and transcriptomics. Our review aims to facilitate the exploration of novel molecular mechanisms and the development of innovative clinical treatment strategies for hepatoblastoma.

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