CHROMOSOMAL ABERRATIONS AND POLYMORPHISM OF GENES OF XENOBIOTICS BIOTRANSFORMATION AND DNA REPAIR ENZYMES IN HEAT POWER INDUSTRY WORKERS

Abstract

The paper presents the results of researching the connection between frequency of chromosomal aberrations and polymorphic variants of genes of xenobiotics biotransformation and DNA repair enzymes in heat power industry workers. The authors show that in the experimental group the frequency of metaphases with aberrations was – 3,91 ± 0,15 %, which was statistically significantly higher than in the control group: 2,06 ± 0,17 %. Cytogenetic disorders did not depend on sex, age and working experience. The comparative analysis of polymorphic loci of genes of xenobiotics biotransformation and DNA repair enzymes in groups of major production facilities workers and control donors showed statistically significant differences in the incidence of the major TT and heterozygous TG genotypes of the APE1 gene. The frequency of chromosomal abnormalities was significantly higher in holders of GSTT1 «0/0», GA genotypes of the XRCC1 gene, TG genotype of the APE1 gene – in the experimental group; GSTM1 «0/0», GA of the XRCC1 gene, TC of the ADPRT gene – in the control group. It has been established, that in individuals with the combination of GSTM1 «0/0» and GSTT1 «0/0» levels chromosomal aberrations are significantly higher than in the the examinees with the «protective» form of these genes.

Keywords

• heat power industry
• chromosomal aberrations
• genes of xenobiotics biotransformation enzymes
• genes of dna repair enzymes