A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

Gourish Mondal; Meredith Stevers; Benjamin Goode; Alan Ashworth; David A. Solomon

doi:10.1038/s41467-019-09659-z

Nature Communications (Apr 2019)

A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

Gourish Mondal,
Meredith Stevers,
Benjamin Goode,
Alan Ashworth,
David A. Solomon

Affiliations

Gourish Mondal: Department of Pathology, University of California
Meredith Stevers: Department of Pathology, University of California
Benjamin Goode: Department of Pathology, University of California
Alan Ashworth: UCSF Helen Diller Family Comprehensive Cancer Center
David A. Solomon: Department of Pathology, University of California

DOI: https://doi.org/10.1038/s41467-019-09659-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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Cohesin complex mediates cohesion of sister chromatids and DNA loop formation. Here the authors show another role of cohesin in replication fork progression, suggesting a potential therapeutic strategy for cohesin-mutant cancers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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