Estrogen-related receptor α (ERRα) functions in the hypoxic injury of microglial cells

Abstract

Hypoxia is a common pathological condition after spinal cord injury. Oestrogen-related receptor alpha (ERRα), as a key regulator of energy metabolism and mitochondrial functions, plays an important role in maintaining cell homeostasis. However, its role in hypoxic spinal microglia has not been fully elaborated. This study investigated the receptor’s activity when these cells are hypoxic and used as an in vitro model.

Keywords

• spinal cord injury
• microglia
• oestrogen-related receptor alpha
• cobalt chloride
• nuclear factor-kappa b