Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

Michael Ramirez; Satwik Rajaram; Robert J. Steininger; Daria Osipchuk; Maike A. Roth; Leanna S. Morinishi; Louise Evans; Weiyue Ji; Chien-Hsiang Hsu; Kevin Thurley; Shuguang Wei; Anwu Zhou; Prasad R. Koduru; Bruce A. Posner; Lani F. Wu; Steven J. Altschuler

doi:10.1038/ncomms10690

Nature Communications (Feb 2016)

Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

Michael Ramirez,
Satwik Rajaram,
Robert J. Steininger,
Daria Osipchuk,
Maike A. Roth,
Leanna S. Morinishi,
Louise Evans,
Weiyue Ji,
Chien-Hsiang Hsu,
Kevin Thurley,
Shuguang Wei,
Anwu Zhou,
Prasad R. Koduru,
Bruce A. Posner,
Lani F. Wu,
Steven J. Altschuler

Affiliations

Michael Ramirez: Department of Pharmaceutical Chemistry, University of California, San Francisco
Satwik Rajaram: Department of Pharmaceutical Chemistry, University of California, San Francisco
Robert J. Steininger: Green Center for Systems Biology, University of Texas Southwestern Medical Center
Daria Osipchuk: Department of Pharmaceutical Chemistry, University of California, San Francisco
Maike A. Roth: Department of Pharmaceutical Chemistry, University of California, San Francisco
Leanna S. Morinishi: Department of Pharmaceutical Chemistry, University of California, San Francisco
Louise Evans: Department of Pharmaceutical Chemistry, University of California, San Francisco
Weiyue Ji: Department of Pharmaceutical Chemistry, University of California, San Francisco
Chien-Hsiang Hsu: Department of Pharmaceutical Chemistry, University of California, San Francisco
Kevin Thurley: Department of Pharmaceutical Chemistry, University of California, San Francisco
Shuguang Wei: Department of Biochemistry, University of Texas Southwestern Medical Center
Anwu Zhou: Department of Biochemistry, University of Texas Southwestern Medical Center
Prasad R. Koduru: Department of Pathology, University of Texas Southwestern Medical Center
Bruce A. Posner: Department of Biochemistry, University of Texas Southwestern Medical Center
Lani F. Wu: Department of Pharmaceutical Chemistry, University of California, San Francisco
Steven J. Altschuler: Department of Pharmaceutical Chemistry, University of California, San Francisco

DOI: https://doi.org/10.1038/ncomms10690
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechanism give rise to the drug-resistant persister state.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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