Nature Communications (Mar 2022)
Tau deposition patterns are associated with functional connectivity in primary tauopathies
- Nicolai Franzmeier,
- Matthias Brendel,
- Leonie Beyer,
- Luna Slemann,
- Gabor G. Kovacs,
- Thomas Arzberger,
- Carolin Kurz,
- Gesine Respondek,
- Milica J. Lukic,
- Davina Biel,
- Anna Rubinski,
- Lukas Frontzkowski,
- Selina Hummel,
- Andre Müller,
- Anika Finze,
- Carla Palleis,
- Emanuel Joseph,
- Endy Weidinger,
- Sabrina Katzdobler,
- Mengmeng Song,
- Gloria Biechele,
- Maike Kern,
- Maximilian Scheifele,
- Boris-Stephan Rauchmann,
- Robert Perneczky,
- Michael Rullman,
- Marianne Patt,
- Andreas Schildan,
- Henryk Barthel,
- Osama Sabri,
- Jost J. Rumpf,
- Matthias L. Schroeter,
- Joseph Classen,
- Victor Villemagne,
- John Seibyl,
- Andrew W. Stephens,
- Edward B. Lee,
- David G. Coughlin,
- Armin Giese,
- Murray Grossman,
- Corey T. McMillan,
- Ellen Gelpi,
- Laura Molina-Porcel,
- Yaroslau Compta,
- John C. van Swieten,
- Laura Donker Laat,
- Claire Troakes,
- Safa Al-Sarraj,
- John L. Robinson,
- Sharon X. Xie,
- David J. Irwin,
- Sigrun Roeber,
- Jochen Herms,
- Mikael Simons,
- Peter Bartenstein,
- Virginia M. Lee,
- John Q. Trojanowski,
- Johannes Levin,
- Günter Höglinger,
- Michael Ewers
Affiliations
- Nicolai Franzmeier
- Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich
- Matthias Brendel
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Leonie Beyer
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Luna Slemann
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Gabor G. Kovacs
- Center for Neurodegenerative Disease Research (CNDR), Institute On Aging and Department of Pathology & Laboratory Medicine, University of Pennsylvania
- Thomas Arzberger
- Munich Cluster for Systems Neurology (SyNergy)
- Carolin Kurz
- German Center for Neurodegenerative Diseases (DZNE)
- Gesine Respondek
- German Center for Neurodegenerative Diseases (DZNE)
- Milica J. Lukic
- German Center for Neurodegenerative Diseases (DZNE)
- Davina Biel
- Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich
- Anna Rubinski
- Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich
- Lukas Frontzkowski
- Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich
- Selina Hummel
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Andre Müller
- Life Molecular Imaging GmbH
- Anika Finze
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Carla Palleis
- Munich Cluster for Systems Neurology (SyNergy)
- Emanuel Joseph
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Endy Weidinger
- Department of Neurology, University Hospital of Munich, LMU Munich
- Sabrina Katzdobler
- Department of Neurology, University Hospital of Munich, LMU Munich
- Mengmeng Song
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Gloria Biechele
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Maike Kern
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Maximilian Scheifele
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Boris-Stephan Rauchmann
- Department of Radiology, University Hospital of Munich, LMU Munich
- Robert Perneczky
- Munich Cluster for Systems Neurology (SyNergy)
- Michael Rullman
- Department of Nuclear Medicine, University Hospital Leipzig
- Marianne Patt
- Department of Nuclear Medicine, University Hospital Leipzig
- Andreas Schildan
- Department of Nuclear Medicine, University Hospital Leipzig
- Henryk Barthel
- Department of Nuclear Medicine, University Hospital Leipzig
- Osama Sabri
- Department of Nuclear Medicine, University Hospital Leipzig
- Jost J. Rumpf
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Matthias L. Schroeter
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Joseph Classen
- Department of Neurology, University Hospital Leipzig
- Victor Villemagne
- Department of Molecular Imaging & Therapy, Austin Health
- John Seibyl
- InviCRO, LLC
- Andrew W. Stephens
- Life Molecular Imaging GmbH
- Edward B. Lee
- Center for Neurodegenerative Disease Research (CNDR), Institute On Aging and Department of Pathology & Laboratory Medicine, University of Pennsylvania
- David G. Coughlin
- Frontotemporal Degeneration Center, University of Pennsylvania
- Armin Giese
- Center for Neuropathology and Prion Research, LMU Munich
- Murray Grossman
- Frontotemporal Degeneration Center, University of Pennsylvania
- Corey T. McMillan
- Frontotemporal Degeneration Center, University of Pennsylvania
- Ellen Gelpi
- Neurological Tissue Bank and Neurology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CERCA
- Laura Molina-Porcel
- Neurological Tissue Bank and Neurology Department, Hospital Clínic de Barcelona, Universitat de Barcelona, IDIBAPS, CERCA
- Yaroslau Compta
- Parkinson’s Disease & Movement Disorders Unit, Hospital Clínic / IDIBAPS / CIBERNED (CB06/05/0018-ISCIII), / European Reference Network for Rare Neurological Diseases (ERN-RND) / Institut de Neurociències (Maria de Maeztu Center), Universitat de Barcelona
- John C. van Swieten
- Department of Neurology, Erasmus Medical Centre
- Laura Donker Laat
- Department Clinical Genetics, Erasmus Medical Center
- Claire Troakes
- London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, Kings College London
- Safa Al-Sarraj
- London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, Kings College London
- John L. Robinson
- Center for Neurodegenerative Disease Research (CNDR), Institute On Aging and Department of Pathology & Laboratory Medicine, University of Pennsylvania
- Sharon X. Xie
- Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania
- David J. Irwin
- Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich
- Sigrun Roeber
- Center for Neuropathology and Prion Research, LMU Munich
- Jochen Herms
- German Center for Neurodegenerative Diseases (DZNE)
- Mikael Simons
- German Center for Neurodegenerative Diseases (DZNE)
- Peter Bartenstein
- Department of Nuclear Medicine, University Hospital of Munich, LMU Munich
- Virginia M. Lee
- Center for Neurodegenerative Disease Research (CNDR), Institute On Aging and Department of Pathology & Laboratory Medicine, University of Pennsylvania
- John Q. Trojanowski
- Center for Neurodegenerative Disease Research (CNDR), Institute On Aging and Department of Pathology & Laboratory Medicine, University of Pennsylvania
- Johannes Levin
- Munich Cluster for Systems Neurology (SyNergy)
- Günter Höglinger
- German Center for Neurodegenerative Diseases (DZNE)
- Michael Ewers
- Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich
- DOI
- https://doi.org/10.1038/s41467-022-28896-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
