Disentangling PTEN-cooperating tumor suppressor gene networks in cancer

Abstract

We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the functional and clinical relevance of several promising candidates for human prostate cancer.

Keywords

• akap13
• celf2
• pard3
• prostate cancer
• pten
• sleeping beauty
• transposon
• tumor suppressor gene
• wac
• zbtb20