Nature Communications (Nov 2021)
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy
- Matthias Kettwig,
- Katharina Ternka,
- Kristin Wendland,
- Dennis Manfred Krüger,
- Silvia Zampar,
- Charlotte Schob,
- Jonas Franz,
- Abhishek Aich,
- Anne Winkler,
- M. Sadman Sakib,
- Lalit Kaurani,
- Robert Epple,
- Hauke B. Werner,
- Samy Hakroush,
- Julia Kitz,
- Marco Prinz,
- Eva Bartok,
- Gunther Hartmann,
- Simone Schröder,
- Peter Rehling,
- Marco Henneke,
- Susann Boretius,
- A. Alia,
- Oliver Wirths,
- Andre Fischer,
- Christine Stadelmann,
- Stefan Nessler,
- Jutta Gärtner
Affiliations
- Matthias Kettwig
- Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University
- Katharina Ternka
- Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University
- Kristin Wendland
- Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University
- Dennis Manfred Krüger
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE)
- Silvia Zampar
- Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Georg August University
- Charlotte Schob
- Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University
- Jonas Franz
- Institute of Neuropathology, University Medical Center Göttingen, Georg August University
- Abhishek Aich
- Department of Cellular Biochemistry, University Medical Center Göttingen, Georg August University
- Anne Winkler
- Institute of Neuropathology, University Medical Center Göttingen, Georg August University
- M. Sadman Sakib
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE)
- Lalit Kaurani
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE)
- Robert Epple
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE)
- Hauke B. Werner
- Department of Neurogenetics, Max Planck Institute of Experimental Medicine
- Samy Hakroush
- Institute of Pathology, University Medical Center Göttingen, Georg August University
- Julia Kitz
- Institute of Pathology, University Medical Center Göttingen, Georg August University
- Marco Prinz
- Institute of Neuropathology, Faculty of Medicine, University of Freiburg
- Eva Bartok
- Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn
- Gunther Hartmann
- Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn
- Simone Schröder
- Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University
- Peter Rehling
- Department of Cellular Biochemistry, University Medical Center Göttingen, Georg August University
- Marco Henneke
- Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University
- Susann Boretius
- Functional Imaging Laboratory, German Primate Center, Leibniz Institute for Primate Research
- A. Alia
- Institute for Medical Physics and Biophysics, University of Leipzig
- Oliver Wirths
- Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Georg August University
- Andre Fischer
- Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE)
- Christine Stadelmann
- Institute of Neuropathology, University Medical Center Göttingen, Georg August University
- Stefan Nessler
- Institute of Neuropathology, University Medical Center Göttingen, Georg August University
- Jutta Gärtner
- Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen, Georg August University
- DOI
- https://doi.org/10.1038/s41467-021-26880-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Studies on interferon-driven brain pathology have so far been hampered by the lack of appropriate animal models. Here the authors characterize RNASET2-deficient mice and show that neuroinflammation and brain atrophy are IFNAR1-dependent.
