Research progress in Beclin-1 and P62 in osteoporosis

Abstract

Osteoporosis （OP） is a bone disease characterized by systemic bone loss and destruction of bone microstructure. The fundamental cause is the imbalance between bone formation and bone resorption mediated by osteoblasts and osteoclasts，and bone resorption is greater than bone formation. Autophagy plays an important role in the occurrence and development of osteoporosis，and the change of autophagy level is a key factor affecting bone balance. Studies have confirmed that autophagy-related molecules of Beclin-1 and P62 directly regulate the formation of autophagosomes at different levels，thus affecting the occurrence and development of OP. In this article，the expression mechanism，functional characteristics and targeted therapy of Beclin-1 and P62 in OP were reviewed，aiming to provide a theoretical basis for the prevention，treatment and subsequent research of OP.

Keywords

• autophagy|osteoporosis|p62|beclin-1|targeted therapy