Patient Preference and Adherence (Nov 2020)

Patient-Reported Outcomes and Impact of Type 2 Diabetes: A Cross-Sectional Study in the Kingdom of Saudi Arabia

  • Gelhorn HL,
  • Boye KS,
  • Shalhoub H,
  • Matza LS,
  • Jordan JB,
  • Alhammad A,
  • Anand SB,
  • Ekhzaimy AA,
  • Strizek A

Journal volume & issue
Vol. Volume 14
pp. 2231 – 2242

Abstract

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Heather L Gelhorn,1 Kristina S Boye,2 Huda Shalhoub,1 Louis S Matza,1 Jessica B Jordan,1 Ali Alhammad,3 Savita B Anand,4 Aishah A Ekhzaimy,5 Alena Strizek6 1Evidera, Bethesda, MD, USA; 2Eli Lilly and Company, Indianapolis, IN, USA; 3Eli Lilly and Company, Riyadh, Kingdom of Saudi Arabia; 4Evidera, London, UK; 5King Saud University, King Saud University Medical City, Riyadh, Kingdom of Saudi Arabia; 6Eli Lilly, Sydney, AustraliaCorrespondence: Heather L GelhornEvidera, 7101 Wisconsin Avenue, Suite 1400, Bethesda, MD 20814, USATel +1 970-363-7333Email [email protected]: The Kingdom of Saudi Arabia (KSA) has the second highest prevalence of type 2 diabetes mellitus (T2DM) in the Middle East. There is a paucity of research on the experiences and treatment preferences of patients with T2DM in KSA. This study explored Saudi patients’ health-related quality of life, eating habits, experiences during Ramadan, and preference between two glucagon-like peptide-1 receptor agonist (GLP-1 RA) treatment devices.Methods: A cross-sectional, observational study was conducted in three cities in KSA. Participants completed sociodemographic and clinical forms, EQ-5D-5L, Impact of Weight on Self-Perceptions, and a diabetes treatment survey. Participants also viewed instructional videos on GLP-1 RA injection devices and indicated their device preference.Results: Of the 310 participants, 53% were male. The mean age was 43 years (range: 30.0– 75.0), duration since diabetes diagnosis was 6.3 years (range: 0.2– 27.1), the most commonly reported last HbA1c level was between ≥ 7.1% and 8% (45%). The mean EQ-5D-5L index score was 0.90, with some participants reporting problems with pain/discomfort (34.5%) and usual activities (33.2%). Patients reported a low-to-moderate impact of weight on self-perception. In preparation for Ramadan, participants sought physician advice on diabetes management (37%) and/or increased checks of their blood glucose (37%). After watching the videos, 89% (n=277) of participants indicated a device preference, with significantly more preferring the dulaglutide device (n=186, 67%) over the semaglutide device (n=91, 33%) (p< 0.0001).Conclusion: This study indicates that T2DM has a significant social, emotional, and behavioral impact on the lives of patients in KSA.Keywords: Kingdom of Saudi Arabia, patient-reported outcomes, type 2 diabetes, preferences, impacts, health-related quality of life

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